Caspase-1 (p20) (clone Casper-1) biotin, anti-mouse
€274.00
In stock
SKU
ARP-23-B0042B
Catalog Number: 23-B0042B
Size: 25 µg
Isotype: Mouse IgG1
Size: 25 µg
Isotype: Mouse IgG1
Decription:
Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
Synonyms: Interleukin-1 beta Convertase, IL-1BC, Interleukin-1 beta-converting Enzyme, ICE
Clone: Casper-1
Isotype: Mouse IgG1
Immunogen: Recombinant mouse caspase-1.
Reactivity: mouse
Specificity: Recognizes endogenous full-length and activated (p20 fragment) mouse caspase-1.
Form: Biotin conjugate, in PBS containing 0.02% sodium azide.
Applications:
Western Blot (see online protocol): (1?g/ml) (no need to precipitate the cell supernatant for the detection of caspase-1 (mouse) upon inflammasome activation) Immunohistochemistry: (1:500; paraffin sections)
Immunoprecipitation: (1:200)
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 0.5mg/ml
Storage: 2-8C
Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
Synonyms: Interleukin-1 beta Convertase, IL-1BC, Interleukin-1 beta-converting Enzyme, ICE
Clone: Casper-1
Isotype: Mouse IgG1
Immunogen: Recombinant mouse caspase-1.
Reactivity: mouse
Specificity: Recognizes endogenous full-length and activated (p20 fragment) mouse caspase-1.
Form: Biotin conjugate, in PBS containing 0.02% sodium azide.
Applications:
Western Blot (see online protocol): (1?g/ml) (no need to precipitate the cell supernatant for the detection of caspase-1 (mouse) upon inflammasome activation) Immunohistochemistry: (1:500; paraffin sections)
Immunoprecipitation: (1:200)
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 0.5mg/ml
Storage: 2-8C
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