Caspase-1(P20) polyclonal, anti-human

Quantity: 100 µg

Background:
Caspase 1 is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, IL18, and IL33 precursor proteins. It belongs to a family of cysteine proteases known as caspases that always cleave proteins following an aspartic acid residue. The Caspase1 gene consists of 10 exons spanning at least 10.6 kb. The Caspase 1 gene is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas, by Southern DNA blot analysis of rodent-human hybrids and by in situ hybridization to normal human metaphase chromosomes. Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages.

Description:
Rabbit IgG polyclonal antibody for Caspase-1 (CASP1) detection. Tested with WB, IHC-P in Human.

Synonyms:
CASP 1 antibody, CASP-1 antibody, CASP1 antibody, Caspase 1 apoptosis related cysteine peptidase antibody, Caspase 1 apoptosis related cysteine protease antibody, Caspase-1 subunit p20 antibody, Caspase1 antibody, ICE antibody, IL 1 beta converting enzyme antibody, IL 1BC antibody, IL-1 beta-converting enzyme antibody, IL-1BC antibody, IL1 beta converting enzyme antibody, IL1B convertase antibody, IL1BC antibody, IL1BCE antibody, Interleukin 1 beta convertase antibody, Interleukin 1 beta convertase precursor antibody, Interleukin 1 beta converting enzyme antibody, Interleukin 1B converting enzyme antibody, Interleukin-1 beta convertase antibody, Interleukin-1 beta-converting enzyme antibody, P45 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human CASP1(135-152aa CSLEEAQRIWKQKSAEIY).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.