Caspase-10 polyclonal, anti-human

Quantity: 100 µg

Background:
Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene. The Caspase 10 gene contains 11 exons and spans about 48 kb. This gene is mapped to 2q33.1. It is transcribed in the centromere-to-telomere direction.This gene encodes a protein that is a member of the cysteine-aspartic acid protease(caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Description:
Rabbit IgG polyclonal antibody for Caspase-10 (CASP10) detection. Tested with WB, IHC-P in Human.

Synonyms:
ALPS 2 antibody, ALPS2 antibody, Apoptosis related cysteine peptidase antibody, Apoptotic protease Mch 4 antibody, Apoptotic protease Mch-4 antibody, CASP 10 antibody, CASP-10 antibody, CASP10 antibody, CASP10 protein antibody, CASPA_HUMAN antibody, Caspase 10 apoptosis related cysteine peptidase antibody, Caspase 10 apoptosis related cysteine protease antibody, Caspase-10 subunit p12 antibody, Caspase10 antibody, FADD Like Ice 2 antibody, FADD like ICE2 antibody, Fas Associated Death Domain Protein antibody, FAS associated death domain protein interleukin 1B converting enzyme 2 antibody, FAS-associated death domain protein interleukin-1B-converting enzyme 2 antibody, FLICE 2 antibody, FLICE2 antibody, ICE Like Apoptotic Protease 4 antibody, ICE-like apoptotic protease 4 antibody, Interleukin 1B Converting Enzyme 2 antibody, MCH 4 antibody, MCH4 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human CASP10(220-236aa VKTFLEALPRAAVYRMN).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.