Caspase-12 polyclonal, anti-human

Quantity: 100 µg

Background:
Caspase 12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The CASP12 gene was mapped to chromosome 11q22.3. Csp12L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis. The estrogen-mediated inhibition of CSP12L expression is a built-in mechanism that has evolved to protect females from infection by favoring a more robust inflammatory response to pathogens, perhaps notably in childbirth.

Description:
Rabbit IgG polyclonal antibody for Inactive caspase-12 (CASP12) detection. Tested with WB, IHC-P in Human.

Synonyms:
Apoptosis related cysteine protease antibody, CASP 12 antibody, CASP-12 antibody, casp12 antibody, CASP12P1 antibody, caspase 12(gene/pseudogene) antibody, caspase 12 pseudogene 1 antibody, Caspase 12 psuedogene 1 antibody, Caspase12 antibody, CASPC_HUMAN antibody, Inactive caspase-12 antibody, OTTHUMP00000207032 antibody, UNQ9415 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human Caspase-12(71-84aa KIFREHLWNSKKQL).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.