Caspase-14 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene. CASP14 belongs the evolutionarily conserved caspase family. CASP14 was assigned to chromosome 19p13.1. Using Northern blot and semiquantitative RT-PCR analyses, it was showed that CASP14 was transcriptionally upregulated during maintenance of confluent cultures of human epidermal keratinocytes. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. Caspase 14 seems to play a role in keratinocyte differentiation and cornification and probably regulates maturation of the epidermis by proteolytically processing filaggrin.

Description:
Rabbit IgG polyclonal antibody for Inactive Caspase-14 (CASP14) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
Apoptosis related cysteine protease antibody, CASP 14 antibody, CASP-14 antibody, CASP14 antibody, Caspase 14 apoptosis related cysteine protease antibody, Caspase 14 precursor antibody, Caspase-14 subunit p10 antibody, Caspase14 antibody, CASPE_HUMAN antibody, MGC119078 antibody, MGC119079 antibody, MICE antibody, Mini ICE antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Caspase-14(223-242aa KARKTNPEIQSTLRKRLYLQ), different from the related rat and mouse sequences by four amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.