Caspase-3 polyclonal, anti-human, mouse, rat

Protein Family: Enzymes, Peptidases

Pathway and Disease: Cancers, Cell Growth and Death, Immune System, Signal Transduction, Neurodegenerative Disorders, Infectious Diseases

Description:
Caspase-3 (CASP-3) is involved in the activation of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Caspase-3 cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase-3 cleaves and activates caspase-6, -7 and -9, and is involved in the cleavage of huntingtin.

Alternate Names: Caspase-3, CASP-3, Apopain, Cystein protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, SCA-1, CASP3, CPP32

Application Notes: E: 1:10,000-1:50,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P42574

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Caspase-3.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.2, with 0.02% sodium azide, 0.5% BSA. Antibody was antigen affinity purified.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.