Caspase 4 Rabbit polyclonal antibody, anti-human, mouse, rat

Background:
Catalytic activity:Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.|Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.|PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.|Belongs to the peptidase C14A family.|Contains 1 CARD domain.|subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers| each one formed by a small and a large subunit.|tissue specificity:Widely expressed| with highest levels in spleen and lung. Moderate expression in heart and liver| low expression in skeletal muscle| kidney and testis. Not found in the brain.|

Research Area: Cancer, Cell biology, Metabolism

Synonyms: Caspase 4 , p10, Cleaved-Ala290, Caspase-4, CASP-4, EC 3.4.22.57, ICE, rel-II, Protease ICH-2, Protease TX, Caspase-4 subunit 1, Caspase-4 subunit 2,

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year