Caspase-7 Polyclonal Antibody

Background:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Research Area: Cancer, Cell Biology, Metabolism

Synonyms:
CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3, caspase-7, Casp7

Immunogen: Recombinant fusion protein of human Caspase-7 (NP_001218.1).

Swissprot: P55210
Gene ID: 840

Calculated MW: 28 kDa/31 kDa/34 kDa/37 kDa
Observed MW: 37 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.