Caspase-8 polyclonal, anti-human

Quantity: 100 µg

Background:
Caspase 8 is a caspase protein. It most likely acts upon caspase 3. This gene encodes a member of the cysteine-aspartic acid protease(caspase) family. The human CASP8 gene, whose product is also known as caspase 8 and FLICE, encodes an interleukin-1beta converting enzyme(ICE)-related cysteine protease that is activated by the engagement of several different death receptors. Caspase 8 is immediately recruited to the Fas receptor once it oligomerizes, and its protease activity is crucial for the apoptotic response generated by the resulting death-inducing signaling complex(DISC). This gene contains at least 11 exons spanning approximately 30kb on human chromosome band 2q33-34. This region of human chromosome 2 was previously reported as the location of the CASP10 gene, whose product is closely related to caspase 8. Caspase-8 deficiency in humans is compatible with normal development and shows that caspase-8 has a postnatal role in immune activation of naive lymphocytes.

Description:
Rabbit IgG polyclonal antibody for Caspase-8 (CASP8) detection. Tested with WB, IHC-P in Human.

Synonyms:
ALPS2B antibody, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein antibody, Apoptosis related cysteine peptidase antibody, Apoptotic cysteine protease antibody, Apoptotic protease Mch 5 antibody, Apoptotic protease Mch-5 antibody, Apoptotic protease Mch5 antibody, CAP 4 antibody, CAP4 antibody, CASP 8 antibody, CASP-8 antibody, CASP8 antibody, CASP8_HUMAN antibody, Caspase 8 antibody, Caspase 8 apoptosis related cysteine peptidase antibody, Caspase-8 subunit p10 antibody, Caspase8 antibody, CED 3 antibody, FADD homologous ICE/CED 3 like protease antibody, FADD Homologous ICE/CED3 Like Protease antibody, FADD Like ICE antibody, FADD-homologous ICE/CED-3-like protease antibody, FADD-like ICE antibody, FLICE antibody, FLJ17672 antibody, ICE like apoptotic protease 5 antibody, ICE-like apoptotic protease 5 antibody, MACH alpha 1/2/3 protein antibody, MACH antibody, MACH beta 1/2/3/4 protein antibody, MCH 5 antibody, MCH5 antibody, MGC78473 antibody, MORT1 associated CED 3 homolog antibody, MORT1 associated CED3 homolog antibody, MORT1-associated CED-3 homolog antibody, OTTHUMP00000163717 antibody, OTTHUMP00000163720 antibody, OTTHUMP00000163724 antibody, OTTHUMP00000163725 antibody, OTTHUMP00000165062 antibody, OTTHUMP00000165063 antibody, OTTHUMP00000165064 antibody, OTTHUMP00000206552 antibody, OTTHUMP00000206582 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human Caspase-8(257-277aa NNHNFAKAREKVPKLHSIRDR).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.