Caspase-9 polyclonal, anti-human

Quantity: 100 µg

Background:
CASP9 is also known as MCH6 or APAF3. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Description:
Rabbit IgG polyclonal antibody for Caspase-9 (CASP9) detection. Tested with WB in Human.

Synonyms:
APAF 3 antibody, APAF-3 antibody, APAF3 antibody, Apoptosis related cysteine peptidase antibody, Apoptotic protease activating factor 3 antibody, Apoptotic protease Mch 6 antibody, Apoptotic protease Mch-6 antibody, Apoptotic protease-activating factor 3 antibody, CASP 9 antibody, CASP-9 antibody, CASP9 antibody, CASP9_HUMAN antibody, Caspase 9 apoptosis related cysteine peptidase antibody, Caspase 9 Dominant Negative antibody, Caspase 9c antibody, Caspase-9 antibody, Caspase-9 subunit p10 antibody, Caspase9 antibody, ICE LAP6 antibody, ICE like apoptotic protease 6 antibody, ICE-LAP6 antibody, ICE-like apoptotic protease 6 antibody, MCH6 antibody, PPP1R56 antibody, protein phosphatase 1, regulatory subunit 56 antibody, RNCASP9 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Caspase-9 recombinant protein (Position: E3-D228). Human Caspase-9 shares 63% amino acid (aa) sequence identity with mouse Caspase-9.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.