Caspase12 rabbit polyclonal, anti-human, mouse, rat

Backgroud: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011],proteolysis, apoptosis, virus-infected cell apoptosis, ER-nuclear signaling pathway, response to unfolded protein, cell death, response to organic substance, regulation of cell death, programmed cell death, death, endoplasmic reticulum unfolded protein response, cellular response to stress, cellular response to unfolded protein, response to endoplasmic reticulum stress, regulation of apoptosis, regulation of programmed cell death, response to protein stimulus,apoptosis in response to endoplasmic reticulum stress,

Synonyms: CASP12, Inactive caspase-12, CASP-12

Gene Name: CASP12

Gene ID: 120329

SwissProt ID: Q6UXS9

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.