CASR Polyclonal Antibody

Background:
CASR (Calcium Sensing Receptor) is a Protein Coding gene. Diseases associated with CASR include Hypocalcemia, Autosomal Dominant and Hyperparathyroidism, Neonatal. Among its related pathways are Proton Pump Inhibitor Pathway, Pharmacodynamics and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and protein kinase binding. An important paralog of this gene is GPRC6A.The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

Research Area: Cancer, Metabolism, Neuroscience, Signal Transduction

Synonyms:
Ca sensing receptor, Ca2+ sensing receptor 1, Ca2+ sensing receptor, Calcium sensing receptor, CAR, CaSR, CASR, EIG8, Extracellular calcium sensing receptor, Extracellular calcium sensing receptor [Precursor], Extracellular calcium-sensing receptor, FHH, FIH, GPRC2A, HHC, HHC1, Hypocalciuric hypercalcemia 1, Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism, MGC138441, NSHPT, Parathyroid Ca(2+) sensing receptor 1, Parathyroid Cell calcium sensing receptor, Parathyroid Cell calcium-sensing receptor, PCAR 1, PCaR1

Immunogen: Fusion protein of human CASR

Swissprot: P41180
Gene Accession: BC112236

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.5 mg/mL
Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.