CAST Polyclonal Antibody

Background:
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.

Research Area: Cancer, Cell Biology, Neuroscience

Synonyms:
BS 17, Calpain inhibitor, Calpastatin, Cast, Heart type calpastatin, ICAL, MGC9402, Sperm BS 17 component, Sperm BS-17 component

Immunogen: Recombinant protein of human CAST

Swissprot: P20810
Gene Accession: BC013579

Calculated MW: 77 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.7 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-7560/sc-20779