CATB polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP7367C
Catalog Number: AC-AP7367C
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB19412
Applications: FC, IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB19412
Applications: FC, IHC-P, WB
Datasheet
Request Information
Background:
The protein CATB is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors.
Other Names:
Cathepsin B, APP secretase, APPS, Cathepsin B1, Cathepsin B light chain, Cathepsin B heavy chain, CTSB, CPSB
Target/Specificity:
This CATB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-227 amino acids from the Central region of human CATB.
Antigen Region:
198-227
Antigen Type: Synthetic Peptide
Gene Name: CTSB
Gene ID: 1508
Primary Accession: P07858
NCBI Accession: NP_001899.1;NP_680090.1;NP_680091.1;NP_680092.1;NP_680093.1
Other Accession: Q4R5M2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
The protein CATB is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors.
Other Names:
Cathepsin B, APP secretase, APPS, Cathepsin B1, Cathepsin B light chain, Cathepsin B heavy chain, CTSB, CPSB
Target/Specificity:
This CATB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-227 amino acids from the Central region of human CATB.
Antigen Region:
198-227
Antigen Type: Synthetic Peptide
Gene Name: CTSB
Gene ID: 1508
Primary Accession: P07858
NCBI Accession: NP_001899.1;NP_680090.1;NP_680091.1;NP_680092.1;NP_680093.1
Other Accession: Q4R5M2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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