Catenin, alpha-1 (CTNNA1) (clone 1G5), anti-human

Background:
Recognizes a protein of 102kDa, identified as Catenin, alpha-1. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, α-catenin forms a heterodimer with β-catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-catenin also regulates the beta-catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer.

Other Names:
Alpha E-catenin; Cadherin-associated protein; CAP102; Catenin alpha-1; CTNNA1; Renal carcinoma antigen NY-REN-13

Antigen Type:
Recombinant protein

Gene Name: CTNNA1 (HGNC:2509)
Gene ID: 1495
Primary Accession: P35221
Other Accession: 445981