Catenin beta Monoclonal Antibody

Background:
CTNNB1, also known as β-Catenin, is an evolutionarily conserved, multifunctional intracellular protein. CTNNB1 was originally identified in cell adherens junctions (Ajs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the Ajs, CTNNB1 is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. Deregulation of CTNNB1 activity is associated with multiple diseases including cancers. .

Research Area: Cancer, Cardiovascular, Neuroscience, Signal Transduction, Stem Cells

Synonyms:
Beta catenin, Beta-catenin, Cadherin associated protein, Catenin (cadherin associated protein), beta 1, 88kDa, Catenin beta 1, Catenin beta-1, CATNB, CHBCAT, CTNB1, CTNNB, CTNNB1, DKFZp686D02253, FLJ25606, FLJ37923, OTTHUMP00000162082, OTTHUMP00000165222, OTTHUMP00000165223, OTTHUMP00000209288, OTTHUMP00000209289

Immunogen: Recombinant protein corresponding to Mouse β-catenin

Swissprot: P35222,Q02248,Q9WU82

Calculated MW: 92 kDa
Observed MW: 92 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 420 μg/mL
Dilution: WB 1:500-1:1000, IHC 1:100-1:500

Storage:
Store at -20°C. Avoid freeze / thaw cycles.