Catenin beta Polyclonal Antibody
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In stock
SKU
E-AB-15534
Catalog Number: E-AB-15534
Isotype: Rabbit IgG
Reactivity: human, mouse, rat
Applications: WB,ELISA
Datasheet, Questions? Contact us!
Isotype: Rabbit IgG
Reactivity: human, mouse, rat
Applications: WB,ELISA
Datasheet, Questions? Contact us!
Background:
Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Research Area: Cancer, Cardiovascular, Neuroscience, Signal Transduction, Stem Cells
Synonyms:
Beta catenin, Beta-catenin, Cadherin associated protein, Catenin (cadherin associated protein), beta 1, 88kDa, Catenin beta 1, Catenin beta-1, CATNB, CHBCAT, CTNB1, CTNNB, CTNNB1, DKFZp686D02253, FLJ25606, FLJ37923, OTTHUMP00000162082, OTTHUMP00000165222, OTTHUMP00000165223, OTTHUMP00000209288, OTTHUMP00000209289
Immunogen: Synthetic peptide of human CTNNB1
Swissprot: P35222
Gene Accession: NP_001091680
Calculated MW: 85 kDa
Observed MW: Refer to figures
Purification Method: Affinity purification
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration: 0.6 mg/mL
Dilution: WB 1:500-1:2000
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Alternative for product with catalog number:
sc-133240/sc-133238/sc-133239/sc-53484/sc-53483/sc-7963/sc-69763/sc-59737/sc-59896/sc-59897/sc-65480
Citation(s):
https://pubmed.ncbi.nlm.nih.gov/31830480/
Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Research Area: Cancer, Cardiovascular, Neuroscience, Signal Transduction, Stem Cells
Synonyms:
Beta catenin, Beta-catenin, Cadherin associated protein, Catenin (cadherin associated protein), beta 1, 88kDa, Catenin beta 1, Catenin beta-1, CATNB, CHBCAT, CTNB1, CTNNB, CTNNB1, DKFZp686D02253, FLJ25606, FLJ37923, OTTHUMP00000162082, OTTHUMP00000165222, OTTHUMP00000165223, OTTHUMP00000209288, OTTHUMP00000209289
Immunogen: Synthetic peptide of human CTNNB1
Swissprot: P35222
Gene Accession: NP_001091680
Calculated MW: 85 kDa
Observed MW: Refer to figures
Purification Method: Affinity purification
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration: 0.6 mg/mL
Dilution: WB 1:500-1:2000
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Alternative for product with catalog number:
sc-133240/sc-133238/sc-133239/sc-53484/sc-53483/sc-7963/sc-69763/sc-59737/sc-59896/sc-59897/sc-65480
Citation(s):
https://pubmed.ncbi.nlm.nih.gov/31830480/
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