Catenin gamma JUP monoclonal, anti-human, mouse, rat

Description: Anti-Catenin gamma JUP Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Protein Function:
Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity)..

Other Names: Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3, JUP (HGNC:6207)

Clone Name(s):
Clone: AOBD-10

Subcellular Localization: Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane ; Peripheral membrane protein. Cytoplasmic in a soluble and membrane-associated form.

Gene ID: 3728

Immunogen: A synthesized peptide derived from human Catenin gamma

Calculated MW: 81745

Purification: Affinity-chromatography

Format: Liquid

Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.