Catenin Gamma (Plakoglobin) (clone 15F11), anti-human
€455.00
In stock
SKU
AC-ABO10407
Catalog Number: AC-ABO10407
Size: 100 µg
Isotype: Mouse IgG
Applications: WB, IHC-F, ICC
Datasheet
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Size: 100 µg
Isotype: Mouse IgG
Applications: WB, IHC-F, ICC
Datasheet
Request Information
Description: Mouse IgG monoclonal antibody for Catenin gamma (Plakoglobin), junction plakoglobin ( JUP) detection. Tested with WB, IHC-F, ICC in Human;bovine. No cross reactivity with other proteins.Protein Name: Junction plakoglobin
Protein Function:
Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). .
Other Names: Junction plakoglobin, Jup
Clone Name(s):
15F11
Subcellular Localization: Cell junction, adherens junction . Cell junction, desmosome . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Cytoplasmic in a soluble and membrane-associated form. .
Gene ID: 81679
Immunogen: Recombinant chicken plakoglobin.
Calculated MW: 81801
Purification: Ascites
Format: Lyophilized
Reconstitution: Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Contents: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Concentration (mg/ml): Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Function:
Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). .
Other Names: Junction plakoglobin, Jup
Clone Name(s):
15F11
Subcellular Localization: Cell junction, adherens junction . Cell junction, desmosome . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Cytoplasmic in a soluble and membrane-associated form. .
Gene ID: 81679
Immunogen: Recombinant chicken plakoglobin.
Calculated MW: 81801
Purification: Ascites
Format: Lyophilized
Reconstitution: Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Contents: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Concentration (mg/ml): Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
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