Cateninγ polyclonal, anti-human, mouse, rat

Background:
The catenins, α, β and γ, are proteins which bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. α-catenin was initially described as an E-cadherin associated protein, and since has been shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. β-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. β-catenin has also been found in complexes with the tumor suppressor protein APC. γ-catenin, also known as plakoglobin, binds with α-catenin and N-cadherin. It has been shown that the transmembrane phosphatase PTP? associates with catenin/cadherin complexes and may regulate complex signaling.

Alternative Name:
JUP, ARVD 12, ARVD12, Catenin (cadherin associated protein), gamma 80kDa, catenin (cadherin-associated protein) gamma (80kD), Catenin gamma, CTNNG, Desmoplakin 3, Desmoplakin III, Desmoplakin-3, Desmoplakin3, DesmoplakinIII, DP 3, DP III, DP3, DPIII, gamma catenin, Junction plakoglobin, JUP, OTTHUMP00000164732, OTTHUMP00000164735, OTTHUMP00000164738, PDGB, PKGB, PLAK, PLAKOGLOBIN,

Application Dilution:
WB:1:1,000-1:2,000
ICC:1:100-1:500
IHC:1:50-1:200
FC:1:50-1:100

Specificity: Cateninγ polyclonal antibody detects endogenous levels of Cateninγ protein.

Immunogen:
recombinant protein

MW: 82 kDa

Swiss-Prot: P14923(Human) Q02257(Mouse) Q6P0K8(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.