Cathepsin B polyclonal, anti-human

Quantity: 100 µg

Background:
Cathepsin B is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSB gene. And this gene is mapped to chromosome 8p22. The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. Cathepsin B was once suspected as a candidate protease participating in the conversion of beta-amyloid precursor protein into the amyloid plaques found in Alzheimer's disease patients. However, this function is now known to be mediated by BACE1 protease. It is now thought that cathepsin B can degrade beta-amyloid precursor protein into harmless fragments. Thus, it is conceivable cathepsin B may play a pivotal role in the natural defense against Alzheimer's disease. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. The standard product used in this kit is recombinant human Cathepsin B with the molecular mass of 37KDa.

Description:
Rabbit IgG polyclonal antibody for Cathepsin B (CTSB) detection. Tested with WB in Human.

Synonyms:
Amyloid precursor protein secretase antibody, APP secretase antibody, APPS antibody, CATB_HUMAN antibody, Cathepsin B antibody, Cathepsin B heavy chain antibody, Cathepsin B1 antibody, CathepsinB antibody, CPSB antibody, CTSB antibody, Cysteine protease antibody, OTTHUMP00000116009 antibody, OTTHUMP00000229510 antibody, OTTHUMP00000229511 antibody, OTTHUMP00000229512 antibody, OTTHUMP00000229514 antibody, OTTHUMP00000229515 antibody, OTTHUMP00000229516 antibody, Preprocathepsin B antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Cathepsin B recombinant protein (Position: L80-D333). Human Cathepsin B shares 83% and 84% amino acid (aa) sequences identity with mouse and rat Cathepsin B, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.