Cathepsin D (clone 4G2) (01-2470), anti-human

Decription:
The aspartic protease cathepsin D is one of the major proteolytic enzymes in lysosomes. The cathepsin D gene locates on chromosome 11p15.5 and spans approximately 11 kb with nine exons. Initially synthesized as an inactive precursor of pro-cathepsin D, the enzyme is subsequently converted to its active forms by proteolytic processing. Breast cancer cells, unlike normal cells, secrete high levels of pro-cathepsin D

Synonyms: CTSD,CPSD, CLN10, MGC2311, cathepsin D, cathepsin D (lysosomal aspartyl protease), ceroid-lipofuscinosis, neuronal 10

Clone: 4G2. Anti-human cathepsin D mAb, clone 4G2, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human cathepsin D protein.

Isotype: Mouse IgG2b kappa

Immunogen: Recombinant human Cathepsin D (21-412 aa) purified from E. coli

Reactivity: human

Form: Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

Applications: ELISA, WB (Cell lysate), Immunohistochemistry

NCBI Nr.: NP_001900

Concentration: 0.1 mg/ml

Storage: Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.

References:
Tang,J. (1979) Mol. Cell. Biochem. 26, 93-109
Fujita, H et al., (1991) Biochem. Biophys. Res. Commun. 179, 190-196
Fusek, M et al., (2005) Biomed Papers 149, 43-50
Garcia,M et al., (1996) Stem Cells 14, 642-650