Cathepsin D polyclonal, anti-human

Quantity: 100 µg

Background:
Cathepsin D is a protein that in humans is encoded by the CTSD gene. This proteinase is a member of the peptidase C1 family, having a specificity similar to but narrower than that of pepsin A. It is mapped to 11p15.5. The cDNA encodes a 412-amino acid protein with 20 and 44 amino acids in a pre- and prosegment, respectively. Cathepsin D is one of the lysosomal proteinases. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease and it has been considered as a breast cancer tumor marker.

Description:
Rabbit IgG polyclonal antibody for Cathepsin D (CTSD) detection. Tested with WB, IHC-P in Human.

Synonyms:
CatD antibody, CATD_HUMAN antibody, Cathepsin D heavy chain antibody, Cathepsin D light chain antibody, CathepsinD antibody, CD antibody, Ceroid lipofuscinosis neuronal 10 antibody, CLN10 antibody, CPSD antibody, CTSD antibody, Lysosomal aspartyl peptidase antibody, Lysosomal aspartyl protease antibody, MGC2311 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Cathepsin D recombinant protein (Position: M201-L412). Human Cathepsin D shares 84.4% and 84% amino acid (aa) sequence identity with mouse and rat Cathepsin D, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.