Cathepsin D polyclonal, anti-human, mouse, rat antibody
€285.00
In stock
SKU
AC-ABV10157-100
Catalog Number: AC-ABV10157-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence s µggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer.
Other Names:
CTSD , CLN10, CPSD, MGC2311
Primary Accession: P18242
Other Accession: EDL18143
Gene Name: Ctsd
Gene ID: 13033
Concentration (mg/ml): 0.5 mg/ml
Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence s µggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer.
Other Names:
CTSD , CLN10, CPSD, MGC2311
Primary Accession: P18242
Other Accession: EDL18143
Gene Name: Ctsd
Gene ID: 13033
Concentration (mg/ml): 0.5 mg/ml
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