Cathepsin K polyclonal, anti-human

Quantity: 100 µg

Background:
Cathepsin K, abbreviated CTSK, is an enzyme that in humans is encoded by the CTSK gene. It is mapped to 1q21. The protein encoded by this gene is a lysosomal cysteine protease involved in bone remodeling and resorption. And this protein, which is a member of the peptidase C1 protein family, is expressed predominantly in osteoclasts. Additionally, the enzyme's ability to catabolize elastin, collagen, and gelatin allow it to break down bone and cartilage. This catabolic activity is also partially responsible for the loss of lung elasticity and recoil inemphysema. Cathepsin K inhibitors, such as odanacatib, show great potential in the treatment of osteoporosis. Cathepsin K is degraded by Cathepsin S, called Controlled Cathepsin Cannibalism.

Description:
Rabbit IgG polyclonal antibody for Cathepsin K (CTSK) detection. Tested with WB, IHC-P in Human.

Synonyms:
Cathepsin K antibody, Cathepsin O antibody, Cathepsin O1 antibody, Cathepsin O2 antibody, Cathepsin X antibody, CATK_HUMAN antibody, CTS02 antibody, Ctsk antibody, CTSO antibody, CTSO1 antibody, CTSO2 antibody, MGC23107 antibody, PKND antibody, PYCD antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E. coli-derived human Cathepsin K recombinant protein (Position: A115-M329). Human Cathepsin K shares 86.9% and 88.8% amino acid (aa) sequence identity with mouse and rat Cathepsin K, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.