Cav1.2 Polyclonal Antibody

Background:
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits.

Research Area: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction

Synonyms:
alpha-1 polypeptide, cardiac muscle, isoform 1, L type, CAC1C, CACH 2, CACH2, CACN 2, CACN2, CACNA1C, CACNL1A1, Calcium channel, Calcium channel cardic dihydropyridine sensitive alpha 1 subunit, Calcium channel L type alpha 1 polypeptide isoform 1 cardiac muscle, Calcium channel voltage dependent L type alpha 1C subunit, CaV1.2, CCHL1A1, DHPR alpha 1, DHPR alpha 1 subunit, LQT8, TS, Voltage dependent L type calcium channel alpha 1C subunit, Voltage dependent L type calcium channel subunit alpha 1C, Voltage gated calcium channel alpha subunit Cav1.2, Voltage gated calcium channel subunit alpha Cav1.2, Voltage gated L type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*, Voltage-dependent L-type calcium channel subunit alpha-1C, Voltage-gated calcium channel subunit alpha Cav1.2

Immunogen: Synthetic peptide of human CACNA1C

Swissprot: Q13936
Gene Accession: NP_955630

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-16230/sc-103588/sc-103590/sc-25686