CAV1 polyclonal, anti-human, mouse, rat

Background:
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.

Synonyms: CGL3, PPH3, BSCL3, VIP21, MSTP085

Cellular Location: Cytoplasm

Immunogen:
A synthetic peptide of human CAV1

Gene Symbol: CAV1

Gene ID: 857

Swiss prot: Q03135

Calculated MW: 20kDa

Recommended dilution:
WB 1:1000-5000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.