CaV2.3 polyclonal, anti-human, mouse, rat

Background:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.

Alternative Name:
BII, CACNA1E, CACH6, CACNL1A6, alpha-1 polypeptide, BII, Brain calcium channel II, CAC 1E, CAC1E, CAC1E, CACH 6, CACH6, CACNA1E, Cacnl1 a6, CACNL1A6, Calcium channel, Calcium channel, L type, alpha 1 polypeptide, isoform 6, calcium channel, R type, Cav 2.3, Cchra 1, Cchra1, isoform 6, L type, Voltage dependent R type calcium channel subunit alpha 1E, Voltage gated calcium channel subunit alpha Cav2.3, Voltage-dependent R-type calcium channel subunit alpha-1E, Voltage-gated calcium channel subunit alpha Cav2.3,

Application Dilution:
WB:1:500
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: CaV2.3 polyclonal antibody detects endogenous levels of CaV2.3 protein.

Immunogen:
Synthetic peptide within rat CaV2.3 aa 860-910.

MW: 262 kDa

Swiss-Prot: Q15878(Human) Q61290(Mouse) Q07652(Rat)

Purification & Purity:
Peptide affinity purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.