CBFA2T2 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP16252a
Background:
In acute myeloid leukemia, especially in the M2 subtype,the t(8;21)(q22;q22) translocation is one of the most frequentkaryotypic abnormalities. The translocation produces a chimericgene made up of the 5'-region of the RUNX1 (AML1) gene fused to the3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein isthought to associate with the nuclear corepressor/histonedeacetylase complex to block hematopoietic differentiation. Theprotein encoded by this gene binds to the AML1-MTG8 complex and maybe important in promoting leukemogenesis. Several transcriptvariants are thought to exist for this gene, but the full-lengthnatures of only three have been described.
Other Names:
Protein CBFA2T2, ETO homologous on chromosome 20, MTG8-like protein, MTG8-related protein 1, Myeloid translocation-related protein 1, p85, CBFA2T2, EHT, MTGR1
Gene Name: CBFA2T2
Gene ID: 9139
Primary Accession: O43439
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
In acute myeloid leukemia, especially in the M2 subtype,the t(8;21)(q22;q22) translocation is one of the most frequentkaryotypic abnormalities. The translocation produces a chimericgene made up of the 5'-region of the RUNX1 (AML1) gene fused to the3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein isthought to associate with the nuclear corepressor/histonedeacetylase complex to block hematopoietic differentiation. Theprotein encoded by this gene binds to the AML1-MTG8 complex and maybe important in promoting leukemogenesis. Several transcriptvariants are thought to exist for this gene, but the full-lengthnatures of only three have been described.
Other Names:
Protein CBFA2T2, ETO homologous on chromosome 20, MTG8-like protein, MTG8-related protein 1, Myeloid translocation-related protein 1, p85, CBFA2T2, EHT, MTGR1
Gene Name: CBFA2T2
Gene ID: 9139
Primary Accession: O43439
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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