CBFA2T2 Polyclonal Antibody

Background:
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Synonyms:
CBFA2T2, EHT, MTGR1, ZMYND3, p85

Immunogen: Recombinant fusion protein of human CBFA2T2 (NP_005084.1).

Swissprot: O43439
Gene ID: 9139

Calculated MW: 28 kDa/63 kDa/65 kDa/67 kDa
Observed MW: 72 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IF 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.