CBFA2T3 Polyclonal Antibody

Background:
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
Cbfa2t3, Ccore binding factor runt domain alpha subunit 2 translocated to 3, ETO2, hMTG16, hMTG16a, hMTG16b, MTG16, MTG16, MTG8 related gene 2, MTG8 related protein MTG16a, MTG8 related protein MTG16b, MTG8-related protein 2, MTGR2, Myeloid translocation gene 8 and 16b, Myeloid translocation gene on chromosome 16 protein, Protein CBFA2T3, Zinc finger MYND domain-containing protein 4, ZMYND4

Immunogen: Synthetic peptide of human CBFA2T3

Swissprot: O75081
Gene Accession: NP005178

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.1 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.