CBL polyclonal, anti-human

Quantity: 100 µg

Background:
CBL(Cbl proto-oncogene) is also known as C-CBL, RNF55, CBL2 and E3 ubiquitin protein ligase. CBL is mapped to chromosome 11q23.3-qter by molecular characterization of the breakpoints in 2 somatic cell hybrids. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes(E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

Description:
Rabbit IgG polyclonal antibody for E3 ubiquitin-protein ligase CBL (CBL) detection. Tested with WB in Human.

Synonyms:
4732447J05Rik antibody, C CBL antibody, Cas Br M (murine) ecotropic retroviral transforming sequence antibody, Cas-Br-M (murine) ecotropic retroviral transforming sequence antibody, Casitas B lineage lymphoma proto oncogene antibody, Casitas B-lineage lymphoma proto-oncogene antibody, CBL 2 antibody, cbl antibody, CBL_HUMAN antibody, CBL2 antibody, E3 ubiquitin protein ligase CBL antibody, E3 ubiquitin-protein ligase CBL antibody, Oncogene CBL2 antibody, Proto oncogene c CBL antibody, Proto-oncogene c-CBL antibody, RGD1561386 antibody, RING finger protein 55 antibody, RNF55 antibody, Signal transduction protein CBL antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human CBL recombinant protein (Position: A556-T906). Human CBL shares 84% amino acid (aa) sequence identity with mouse CBL.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.