CBR1 Polyclonal Antibody

Background:
Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q. NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol.

Research Area: Cancer, Cell Biology, Metabolism, Signal Transduction

Synonyms:
15 hydroxyprostaglandin dehydrogenase [NADP+], 15-hydroxyprostaglandin dehydrogenase [NADP+], Carbonyl reductase [NADPH] 1, Carbonyl Reductase 1, CBR 1, CBR1, CBR1, CRN, NADPH dependent carbonyl reductase 1, NADPH-dependent carbonyl reductase 1, Prostaglandin 9 ketoreductase, Prostaglandin 9-ketoreductase, Prostaglandin E(2) 9 reductase, Prostaglandin-E(2) 9-reductase, SDR21C1

Immunogen: Recombinant protein of human CBR1

Swissprot: P16152
Gene Accession: BC002511

Calculated MW: 30 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: WB 1:1000-1:5000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-70215/sc-70212