CBS(NT) polyclonal, anti-human, mouse antibody
€275.00
In stock
SKU
AC-ABV11279-100
Catalog Number: AC-ABV11279-100
Size: 100 µl
Host: Rabbit IgG
Applications: WB, IHC, IF, FC
Datasheet
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Size: 100 µl
Host: Rabbit IgG
Applications: WB, IHC, IF, FC
Datasheet
Request Information
Background:
Strongly expressed in human liver and pancreas, with weaker expression in heart and brain, the cytoplasmic protein cystathionine b-synthase (CBS) operates in the first step of homocysteine transulfuration. CBS, which belongs to the cysteine synthase/cystathionine b-synthase family of proteins, catalyzes the formation of cystathionine from the thrombogenic amino acid homocysteine using pyridoxal phosphate cofactor. Allosteric activation by adenosyl-methionine regulates CBS activity. Deficiencies in CBS are associated with homocystinuria, a recessively inherited error in sulfur amino acid metabolism that affects many organs and tissues. Symptoms of homocytinuria include arteriosclerosis, thrombosis, dislocated optic lenses, mental retardation and skeletal abnormalities.
Other Names:
CBS, Cystathionine beta-synthase, Beta-thionase, Serine sulfhydrase
Primary Accession: P35520
Gene Name: CBS
Gene ID: 102724560;875
Strongly expressed in human liver and pancreas, with weaker expression in heart and brain, the cytoplasmic protein cystathionine b-synthase (CBS) operates in the first step of homocysteine transulfuration. CBS, which belongs to the cysteine synthase/cystathionine b-synthase family of proteins, catalyzes the formation of cystathionine from the thrombogenic amino acid homocysteine using pyridoxal phosphate cofactor. Allosteric activation by adenosyl-methionine regulates CBS activity. Deficiencies in CBS are associated with homocystinuria, a recessively inherited error in sulfur amino acid metabolism that affects many organs and tissues. Symptoms of homocytinuria include arteriosclerosis, thrombosis, dislocated optic lenses, mental retardation and skeletal abnormalities.
Other Names:
CBS, Cystathionine beta-synthase, Beta-thionase, Serine sulfhydrase
Primary Accession: P35520
Gene Name: CBS
Gene ID: 102724560;875
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