CBS polyclonal, anti-human antibody
€310.00
In stock
SKU
AC-ABO10860
Catalog Number: AC-ABO10860
Size: 100 µg
Host: rabbit IgG
Applications: WB, IHC-P
Datasheet
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Size: 100 µg
Host: rabbit IgG
Applications: WB, IHC-P
Datasheet
Request Information
Description: Rabbit IgG polyclonal antibody for E3 ubiquitin-protein ligase SMURF1 (SMURF1) detection. Tested with WB in human, rat.
Protein Name: E3 ubiquitin-protein ligase SMURF1
Background:
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Plays a role in dendrite formation by melanocytes (PubMed:23999003). .
Other Names:
E3 ubiquitin-protein ligase SMURF1, hSMURF1, 2.3.2.26, HECT-type E3 ubiquitin transferase SMURF1, SMAD ubiquitination regulatory factor 1, SMAD-specific E3 ubiquitin-protein ligase 1, SMURF1, KIAA1625
Subcellular Localization: Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .
Tissue Specificity: Expressed in melanocytes (PubMed:23999003). .
Gene ID: 57154
Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human SMURF1 (326-351aa DHNNRTTQFTDPRLHHIMNHQCQLKE), identical to the related mouse sequence.
Calculated MW: 86114
Purification: Immunogen affinity purified.
Format: Lyophilized
Contents: Each vial contains 5mg BSA, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.
Concentration (mg/ml): Add 0.2 ml of distilled water will yield a concentration of 500 µg/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.
Protein Name: E3 ubiquitin-protein ligase SMURF1
Background:
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Plays a role in dendrite formation by melanocytes (PubMed:23999003). .
Other Names:
E3 ubiquitin-protein ligase SMURF1, hSMURF1, 2.3.2.26, HECT-type E3 ubiquitin transferase SMURF1, SMAD ubiquitination regulatory factor 1, SMAD-specific E3 ubiquitin-protein ligase 1, SMURF1, KIAA1625
Subcellular Localization: Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .
Tissue Specificity: Expressed in melanocytes (PubMed:23999003). .
Gene ID: 57154
Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human SMURF1 (326-351aa DHNNRTTQFTDPRLHHIMNHQCQLKE), identical to the related mouse sequence.
Calculated MW: 86114
Purification: Immunogen affinity purified.
Format: Lyophilized
Contents: Each vial contains 5mg BSA, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.
Concentration (mg/ml): Add 0.2 ml of distilled water will yield a concentration of 500 µg/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.
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