CBS polyclonal, anti-human

Quantity: 100 µg

Background:
CBS, Cystathionine Beta-Synthase, catalyzes the first irreversible step of transsulfuration. The CBS enzyme is a homotetramer of 63-kD subunits and requires pyridoxal phosphate and heme for activity. The CBS gene, which is mapped to chromosome 21q22, contains 23 exons, ranging in size from 42 to 299 bp. The human CBS protein can substitute for the endogenous yeast CBS protein in Saccharomyces cerevisiae. The catalytic domain of the CBS protein is located in the N-terminal 409 amino acids, and a regulatory domain is located in the C-terminal 142 amino acids.A mutation that deletes the C-terminal 145 amino acids of CBS could restore activity of several CBS mutant alleles found in homocystinurics.

Description:
Rabbit IgG polyclonal antibody for Cystathionine beta-synthase (CBS) detection. Tested with WB, IHC-P in Human.

Synonyms:
AI047524 antibody, AI303044 antibody, Beta thionase antibody, Beta-thionase antibody, Cbs antibody, Cbs cystathionine beta-synthase antibody, CBS_HUMAN antibody, Cystathionine beta synthase antibody, Cystathionine beta-synthase antibody, EC 4.2.1.22 antibody, HIP 4 antibody, HIP4 antibody, Methylcysteine synthase antibody, MGC18856 antibody, MGC18895 antibody, MGC37300 antibody, OTTHUMP00000109416 antibody, OTTHUMP00000109418 antibody, Serine sulfhydrase antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human CBS(322-342aa KWFKSNDEEAFTFARMLIAQE).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.