CBS polyclonal, anti-human

Background:
Strongly expressed in human liver and pancreas, with weaker expression in heart and brain, the cytoplasmic protein cystathionine b-synthase (CBS) operates in the first step of homocysteine transulfuration. CBS, which belongs to the cysteine synthase/cystathionine b-synthase family of proteins, catalyzes the formation of cystathionine from the thrombogenic amino acid homocysteine using pyridoxal phosphate cofactor. Allosteric activation by adenosyl-methionine regulates CBS activity. Deficiencies in CBS are assoc-iated with homocystinuria, a recessively inherited error in sulfur amino acid metabolism that affects many organs and tissues. Symptoms of homocytinuria include arteriosclerosis, thrombosis, dislocated optic lenses, mental retard-ation and skeletal abnormalities.

Alternative Name:
CBS, AI047524, AI303044, Beta thionase, Beta-thionase, Cbs, Cbs cystathionine beta-synthase, CBS, Cystathionine beta synthase, Cystathionine beta-synthase, EC 4.2.1.22, HIP 4, HIP4, Methylcysteine synthase, MGC18856, MGC18895, MGC37300, OTTHUMP00000109416, OTTHUMP00000109418, Serine sulfhydrase,

Application Dilution:
WB:1:500-1:2,000
ICC:1:50-1:100

Specificity: CBS polyclonal antibody detects endogenous levels of CBS protein.

Immunogen:
Recombinant protein within human CBS aa 400-550.

MW: 61 kDa

Swiss-Prot: P35520(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.