CBX4 polyclonal, anti-human, mouse, rat

Background:
CBX4 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. It is involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. CBX4 is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development .

Synonyms: NBP16, PC2

Cellular Location: Nucleus Nucleus speckle

Immunogen:
Recombinant protein of human CBX4

Gene Symbol: CBX4

Gene ID: 8535

Swiss prot: O00257

Calculated MW: 61kDa

Recommended dilution:
WB 1:500-2000, IP 1:50-200

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.