CBX5 Monoclonal Antibody

Background:
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Tags and Cell Markers

Synonyms:
Antigen p25, CBX5, CBX5, CG8409, Chromobox 5, Chromobox homolog 5 (HP1 alpha homolog, Drosophila), Chromobox homolog 5, Chromobox protein homolog 5, Epididymis luminal protein 25, HEL25, Heterochromatin protein 1 alpha, Heterochromatin protein 1, Heterochromatin protein 1 homolog alpha, HP1 alpha, HP1 alpha homolog, HP1, HP1A, HP1Hs alpha, Su(var)205

Immunogen: Recombinant Protein of HP-1α

Swissprot: P45973
Observed MW: 22 kDa

Purification Method: Protein A purification

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Concentration: 1 mg/mL
Dilution: WB 1:500-2000, IHC 1:50-300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.