cbx7 polyclonal, anti-human
€428.00
In stock
SKU
BS90206
Catalog Number: BS90206
Size: 100 µl
Other Size: 50 µl
Isotype: rabbit IgG
Applications: WB, FC
Questions? Contact us!
Size: 100 µl
Other Size: 50 µl
Isotype: rabbit IgG
Applications: WB, FC
Questions? Contact us!
Background:
CBX7 (Chromobox protein homolog 7) is a 251 amino acid nuclear protein that contains one N-terminal chromo domain and one C-terminal Pc box. Highly expressed in kidney, brain, heart and skeletal muscle, with weaker expression in peripheral blood leukocytes, CBX7 functions as a component of the chromatin-associated polycomb complex (PcG) and is involved in maintaining the transcriptionally repressed state of target genes. Additionally, CBX7 modifies chromatin and is thought to extend the cellular life span of epithelial cells by repressing p14 ARF expression, while simultaneously repressing telomerase activity. Due to its ability to repress the transcription of cell-cycle related proteins, CBX7 is thought to play a role in tumorigenesis, specifically in the development of follicular lymphoma and thyroid cancer.
Alternative Name:
CBX7, Cbx 7, CBX7, Chromobox homolog 7, Chromobox protein homolog 7,
Application Dilution:
WB:1:500-1:2,000
FC:1:50-1:100
Specificity: cbx7 polyclonal antibody detects endogenous levels of cbx7 protein.
Immunogen:
Recombinant protein
Swiss-Prot: O95931(Human)
Purification & Purity:
ProA affinity purified
Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
For research use only, not for use in diagnostic procedure.
CBX7 (Chromobox protein homolog 7) is a 251 amino acid nuclear protein that contains one N-terminal chromo domain and one C-terminal Pc box. Highly expressed in kidney, brain, heart and skeletal muscle, with weaker expression in peripheral blood leukocytes, CBX7 functions as a component of the chromatin-associated polycomb complex (PcG) and is involved in maintaining the transcriptionally repressed state of target genes. Additionally, CBX7 modifies chromatin and is thought to extend the cellular life span of epithelial cells by repressing p14 ARF expression, while simultaneously repressing telomerase activity. Due to its ability to repress the transcription of cell-cycle related proteins, CBX7 is thought to play a role in tumorigenesis, specifically in the development of follicular lymphoma and thyroid cancer.
Alternative Name:
CBX7, Cbx 7, CBX7, Chromobox homolog 7, Chromobox protein homolog 7,
Application Dilution:
WB:1:500-1:2,000
FC:1:50-1:100
Specificity: cbx7 polyclonal antibody detects endogenous levels of cbx7 protein.
Immunogen:
Recombinant protein
Swiss-Prot: O95931(Human)
Purification & Purity:
ProA affinity purified
Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
For research use only, not for use in diagnostic procedure.
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