CCDC88A Polyclonal Antibody

Background:
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Research Area: Cancer, Neuroscience, Signal Transduction

Synonyms:
AKT iphosphorylation enhancer, Akt phosphorylation enhancer, APE, Ccdc88a, Coiled coil domain containing 88A, Coiled coil domain containing protein 88A, Coiled-coil domain-containing protein 88A, FLJ10392, G alpha interacting vesicle associated protein, G alpha-interacting vesicle-associated protein, Galpha interacting vesicle associated protein, Girders of actin filament, Girdin, GIV, GRDN, GRDN, HkRP1, Hook related protein 1, Hook-related protein 1, KIAA1212

Immunogen: Synthetic peptide of human CCDC88A

Swissprot: Q3V6T2
Gene Accession: NP_001129069

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 1 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-133371