CCDC99 Polyclonal Antibody

Background:
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.

Research Area: Cell Biology

Synonyms:
AA409762, Arsenite related gene 1 protein, Arsenite-related gene 1 protein, CCDC 99, Ccdc99, Coiled coil domain containing 99, Coiled-coil domain-containing protein 99, FLJ20364, FLJ40690, hSpindly, MGC124977, Protein Spindly, rhabdomyosarcoma antigen MU RMS 40.4A, Rhabdomyosarcoma antigen MU-RMS-40.4A, Rrhabdomyosarcoma antigen protein MU RMS 40.4A, SPDL1, SPDLY, Spindle apparatus coiled coil domain containing protein 1, Spindle apparatus coiled coil protein 1, Spindly, Spindly homolog

Immunogen: Recombinant protein of human SPDL1

Swissprot: Q96EA4
Gene Accession: BC012568

Calculated MW: 70/59 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.2 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-242387/sc-242388