CCM2 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6875a
Background:
CCM2 is a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells.
Other Names:
Malcavernin, Cerebral cavernous malformations 2 protein, CCM2, C7orf22
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6875a was selected from the N-term region of human CCM2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CCM2
Gene ID: 83605
Primary Accession: Q9BSQ5
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
CCM2 is a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells.
Other Names:
Malcavernin, Cerebral cavernous malformations 2 protein, CCM2, C7orf22
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6875a was selected from the N-term region of human CCM2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CCM2
Gene ID: 83605
Primary Accession: Q9BSQ5
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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