CCM2 polyclonal, anti-human

Background:
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Other Names:
Malcavernin, Cerebral cavernous malformations 2 protein, CCM2, C7orf22

Antigen Types:
Synthetic Peptide

Gene Name:
CCM2
Gene ID:
83605
Primary Accession: Q9BSQ5
Other Accession: NP_113631;83605;216527 (mouse);