CCNC polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6824
Background:
The proliferation of eukaryotic cells is controlled at specific points in the cell cycle, particularly at the G1 to S and the G2 to M transitions. It is well established that the Cdc2 p34-cyclin B protein kinase plays a critical role in the G2 to M transition while cyclin A associates with Cdk2 p33 and functions in S phase. Considerable effort directed towards the identi- fication of G1 cyclins has led to the isolation of cyclin D, cyclin C and cyclin E. Cyclin D corresponds to a putative human oncogene designated PRAD1 which maps at the site of the BCL1 rearrangement in certain lymphomas and leukemias. Cyclin C complexes with the cyclin dependent kinase Cdk8. The cyclin C/Cdk8 complex has been shown to have kinase activity toward the carboxy terminal domain of RNA polymerase II. Two complexes have been identified which contain cyclin C/Cdk8.
Alternative Name:
Cyclin-C, SRB11 homolog, hSRB11, CCNC
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: CCNC polyclonal antibody detects endogenous levels of CCNC protein.
Immunogen:
Recombinant full length Human CCNC.
MW: ~ 33 kDa
Swis Prot.: P24863
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The proliferation of eukaryotic cells is controlled at specific points in the cell cycle, particularly at the G1 to S and the G2 to M transitions. It is well established that the Cdc2 p34-cyclin B protein kinase plays a critical role in the G2 to M transition while cyclin A associates with Cdk2 p33 and functions in S phase. Considerable effort directed towards the identi- fication of G1 cyclins has led to the isolation of cyclin D, cyclin C and cyclin E. Cyclin D corresponds to a putative human oncogene designated PRAD1 which maps at the site of the BCL1 rearrangement in certain lymphomas and leukemias. Cyclin C complexes with the cyclin dependent kinase Cdk8. The cyclin C/Cdk8 complex has been shown to have kinase activity toward the carboxy terminal domain of RNA polymerase II. Two complexes have been identified which contain cyclin C/Cdk8.
Alternative Name:
Cyclin-C, SRB11 homolog, hSRB11, CCNC
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: CCNC polyclonal antibody detects endogenous levels of CCNC protein.
Immunogen:
Recombinant full length Human CCNC.
MW: ~ 33 kDa
Swis Prot.: P24863
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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