CCND2 antibody (clone 3B10), anti-human
€435.00
In stock
SKU
AC-AT1419a
Catalog Number: AC-AT1419a
Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB
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Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB
Request Information AC-AT1419a">Request Information
Background:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.
Other Names:
G1/S-specific cyclin-D2, CCND2
Antigen Type:
Recombinant Protein
Gene Name: CCND2 {ECO:0000303|PubMed:1386336, ECO:0000312|HGNC:HGNC:1583}
Gene ID: 894
NCBI Accession: NP_001750.1
Primary Accession: P30279
Other Accession: BC010958
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.
Other Names:
G1/S-specific cyclin-D2, CCND2
Antigen Type:
Recombinant Protein
Gene Name: CCND2 {ECO:0000303|PubMed:1386336, ECO:0000312|HGNC:HGNC:1583}
Gene ID: 894
NCBI Accession: NP_001750.1
Primary Accession: P30279
Other Accession: BC010958
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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