CCND2 polyclonal (N-term), anti-human

Background:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.

Other Names:
G1/S-specific cyclin-D2, CCND2

Target/Specificity:
This CCND2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CCND2.

Antigen Region:
1-30

Antigen Type: Synthetic Peptide

Gene Name: CCND2 {ECO:0000303|PubMed:1386336, ECO:0000312|HGNC:HGNC:1583}
Gene ID: 894
Primary Accession: P30279
NCBI Accession: NP_001750.1
Other Accession: NP_001750.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.