CCND3 polyclonal (C-term S274), anti-human, mouse
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In stock
SKU
AC-AP20418b
Catalog Number: AC-AP20418b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB43029
Applications: WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB43029
Applications: WB, IHC-P
Datasheet
Request Information
Background:
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Other Names:
G1/S-specific cyclin-D3, CCND3
Target/Specificity:
This CCND3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-281 amino acids from the C-terminal region of human CCND3.
Antigen Region:
252-281
Antigen Type: Synthetic Peptide
Gene Name: CCND3 {ECO:0000303|PubMed:1386336, ECO:0000312|HGNC:HGNC:1585}
Gene ID: 896
Primary Accession: P30281
NCBI Accession: NP_001129489.1;NP_001129597.1;NP_001129598.1;NP_001751.1
Other Accession: P30282; Q3MHH5
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Other Names:
G1/S-specific cyclin-D3, CCND3
Target/Specificity:
This CCND3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-281 amino acids from the C-terminal region of human CCND3.
Antigen Region:
252-281
Antigen Type: Synthetic Peptide
Gene Name: CCND3 {ECO:0000303|PubMed:1386336, ECO:0000312|HGNC:HGNC:1585}
Gene ID: 896
Primary Accession: P30281
NCBI Accession: NP_001129489.1;NP_001129597.1;NP_001129598.1;NP_001751.1
Other Accession: P30282; Q3MHH5
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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