CCNH N-terminal region polyclonal, anti-human, mouse, rat, rabbit, pig, dog, guinea pig, horse, bovine

Background:
This is a rabbit polyclonal antibody against CCNH. It was validated on Western Blot by Abgent. At Abgent we manufacture rabbit polyclonal antibodies on a large scale (200-1000 products/month) of high throughput manner. Our antibodies are peptide based and protein family oriented. We usually provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein.

Other Names:
Cyclin-H, MO15-associated protein, p34, p37, CCNH

Target/Specificity:
Cyclin H regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. It is involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Immunogen:
The immunogen for anti-CCNH antibody: synthetic peptide directed towards the N terminal of human CCNH

Gene Name:
CCNH
Gene Name:
902
Swissprot ID: P51946
NCBI Accession:
NP_001230
Primary Accession: P51946
Other Accession: P51946;NP_001230;NM_001239
Purification: Affinity Purified
Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.