CCNT2 Polyclonal Antibody

Background:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein.

Research Area: Cell Biology, Epigenetics and Nuclear Signaling

Synonyms:
CCNT2, CCNT2, Cyclin T2a, Cyclin T2b, Cyclin-T2, CycT2, FLJ90560, MGC134840, SDS stable vimentin bound DNA fragment HEF42VIM22, Subunit of positive elongation transcription factor b

Immunogen: Synthetic peptide of human CCNT2

Swissprot: O60583
Gene Accession: NP490595

Calculated MW: 81 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.8 mg/mL
Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.